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Gut microbiota compositional shifts may occur within days to weeks (61), whereas meaningful changes in HbA1c require at least 812 weeks of sustained dietary modification, and changes in muscle mass assessed by gold-standard methods require 1224 weeks of combined dietary and exercise intervention

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PPARs as master regulators of carnitine homeostasis Genes regulated by peroxisome proliferator-activated receptor (PPAR) are involved in many biological processes such as fatty acid catabolism, ketogenesis and gluconeogenesis, and also play a key role in the regulation of carnitine homeostasis [189]